Simply Stated: The Creatine Kinase Test; 2000 Jan 31 [cited 2019 Jun 12]; [about 4 screens]. PMC Before joining SelfHacked, she was a research scientist with extensive field and laboratory experience. 2023 Johns Hopkins Arthritis CenterPatient Privacy, RheumTV Patient Education Video Library, The Camille Julia Morgan Arthritis Research and Education Fund, Disease Modifying Antirheumatic Drugs (DMARDs), Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Johns Hopkins Lyme Disease Research Center. Your privacy is important to us. Federal government websites often end in .gov or .mil. Chemotherapy Drugs. Summary. An elevated level of creatine kinase, specifically CK-MB, occurs within hours of a heart attack as the heart muscle cells die. Kenilworth (NJ): Merck & Co., Inc.; c2019. What Are The Best Exercises For A Flat Tummy? Muscular Dystrophy Association. Read up on other health perks of coffee. Here are 17 foods that you should likely avoid, Learn about positive lifestyle changes that may improve your glomerular filtration rate (GFR) and slow the loss of kidney function for people with, Your kidneys act as your bodys filtration system. If elevated CK persists, it is more likely to be due to an underlying health issue. This could contribute to the increased statin X These include: You may also need this test if you had a muscle injury or stroke. Drugs commonly elevate CK Prescription drugs and supplements are an important and common cause of CK elevation, so it is important to carefully review medications the patient is taking. Statinscan cause myalgia, muscle weakness, and rhabdomyolysis. Some pharmaceutical drugs also have the potential to increase CK: Finally, toxins like snake venom or carbon monoxide can increase CK levels [77, 78]. Some studies indicate that healthy black men and women can have significantly higher values than the currently recognized normal range(s) up to 712 and 323 IU/L, respectively [5, 6, 7]. 2013 Aug;23(4):378-87. doi: 10.1123/ijsnem.23.4.378. Information is shared for educational purposes only. After 4 weeks of treatment, subjects performed 45 minutes of eccentric exercise (downhill walking at a -15% grade). Your healthcare provider might test for elevated CK levels to check for muscle damage if they suspect you have a muscular disorder. High levels are a starting point in the diagnostic process. "Well-documented and instructive. There are two types of diabetes type 1 and type 2. Mayo Clinic Staff. Creatinine levels may vary due to factors like by age, sex, race, hydration, or body mass. Available from: KidsHealth from Nemours [Internet]. For more tips from our Medical co-author, including how to exercise to lower your CPK levels, read on. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Yes, it typically takes me 3 days to return CK levels to normal, and 1-2 days to get my BUN in range on a regular protein diet. Approved. Kidney failure: What is kidney failure? The elevation is detected through a simple blood test. That is why men usually have higher CK values than women. Luba has certifications in Pediatric Advanced Life Support (PALS), Emergency Medicine, Advanced Cardiac Life Support (ACLS), Team Building, and Critical Care Nursing. What do I do to lower my CPK level that was elevated due to strenuous exercise? Health Information: Creatine Kinase: Test Overview; [updated 2018 Jun 25; cited 2019 Jun 12]; [about 2 screens]. Allow it to steep for at least 10 minutes. 2023 Healthline Media LLC. Required fields are marked *. An elevated level of creatine kinase is seen in heart attacks, when the heart muscle is damaged, or in conditions that produce damage to the skeletal muscles or brain. Available from: UF Health: University of Florida Health [Internet]. wikiHow, Inc. is the copyright holder of this image under U.S. and international copyright laws. Rheum.TV is an informational platform created to educate patients living with a rheumatic disease. A 24-hour urine sample involves collecting your urine over a period of 24 hours. Your Muscles; [cited 2019 Jun 19]; [about 3 screens]. The Nemours Foundation; c1995-2019. Creatine kinase is often incorrectly referred to as creatinine kinase. Always consult a medical provider for diagnosis and treatment. A small amount of CK in the blood is normal. I am a psychiatrist, recently taking Vastatine and my CPK shows a figure of 1338. WebFew people are aware that exercise, especially intense activity, can significantly alter certain laboratory tests. However, they increase in late pregnancy [90]. So what does it mean if you have high creatinine levels? These conditions can affect blood flow through the kidneys, leading to damage or loss of function. It is possible to be healthy and have higher CK levels. There are many possible causes of high creatinine, some of which may be a one-time occurrence. but is for informational and educational purposes alone. High levels can tell us if there is muscle, heart, or brain damage. Mix a tablespoon of cinnamon in warm water or food and consume once a day. Injury prevention. Some kidney infection symptoms to look out for include: Glomerulonephritis occurs when the parts of your kidneys that filter your blood become inflamed. "A very useful and informative article. Examples can include things such as dehydration or intake of large amounts of protein or the supplement creatine. 7. She specializes in covering general wellness and chronic illness. All of our content is written by scientists and people with a strong science background. To keep your CPK levels low, you need to keep the rest of your bodyespecially your heart and other muscleshealthy. Elevated creatine kinase can be a sign of serious tissue damage or an underlying disease or disorder. DOI: Symptoms that can accompany high creatinine, hopkinsmedicine.org/health/treatment-tests-and-therapies/24hour-urine-collection, nhlbi.nih.gov/health-topics/atherosclerosis, mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/8513, niddk.nih.gov/health-information/diabetes/overview/symptoms-causes, niddk.nih.gov/health-information/kidney-disease/heart-disease, nhlbi.nih.gov/health-topics/heart-failure, cdc.gov/dhdsp/data_statistics/fact_sheets/fs_bloodpressure.htm, mayocliniclabs.com/order-tests/si-unit-conversion.html, niddk.nih.gov/health-information/kidney-disease/kidney-failure/what-is-kidney-failure, niddk.nih.gov/health-information/urologic-diseases/kidney-infection-pyelonephritis/all-content, mayoclinic.org/diseases-conditions/glomerulonephritis/symptoms-causes/syc-20355705, mayoclinic.org/tests-procedures/creatinine-test/about/pac-20384646, 8 Home Remedies to Naturally Lower Your Creatinine Levels, Everything You Should Know About Stage 2 Kidney Disease, 17 Foods to Avoid or Limit If You Have Bad Kidneys. With little FDA oversight, melatonin supplements vary widely in actual dosage, study finds. If you have high CK levels because of kidney failure, your healthcare provider may recommend a change in diet. The CK test requires a simple blood sample. treating problems of your brain, spinal cord and nerves, including these 8 Keeping your brain in shape has major lifelong benefits like enhancing your memory, building new synapses, and possibly helping delay the onset of illnesses like Alzheimers disease. Several chemotherapy drugs like Cisplatin, Carbplatin, Carmustine, Mitomycin and Methotrexate may cause kidney damage and produce elevated creatinine levels. This image may not be used by other entities without the express written consent of wikiHow, Inc.
\n<\/p>


\n<\/p><\/div>"}, {"smallUrl":"https:\/\/www.wikihow.com\/images\/thumb\/e\/e3\/Lower-CPK-Levels-Naturally-Step-17-Version-3.jpg\/v4-460px-Lower-CPK-Levels-Naturally-Step-17-Version-3.jpg","bigUrl":"\/images\/thumb\/e\/e3\/Lower-CPK-Levels-Naturally-Step-17-Version-3.jpg\/aid4510115-v4-728px-Lower-CPK-Levels-Naturally-Step-17-Version-3.jpg","smallWidth":460,"smallHeight":345,"bigWidth":728,"bigHeight":546,"licensing":"

\u00a9 2023 wikiHow, Inc. All rights reserved. The symptoms of acute kidney failure can come on quickly while those of chronic kidney failure develop over time. A study with over 12,000 people found that higher CK was linked to lower hs-CRP, which is a measure of chronic inflammation [79]. We are committed to providing our audience with actionable content and tools to help them make the best decision when it comes to choosing a healthcare professional. CK is a type of protein, known as an enzyme. Cr monohydrate did not reduce CK increases after exercise in statin-treated subjects. 8 Key Things to Know Before Taking Supplements. A study suggests that creatine supplementation may help build muscle and increase creatine kinase activity in athletes [95]. Measuring serum creatine kinase (CK) is a crucial a part of the analysis of sufferers with muscle weak point or myalgia, and of assessing sufferers with myopathies or rhabdomyolysis. I am long distance runner. Available from: University of Rochester Medical Center [Internet]. 4. Add some garlic to your favorite dishes, which is known to lower cholesterol. Can J Appl Physiol. The Healthgrades Editorial Staff is an experienced team of in-house editors, writers and content producers. Creatine phosphokinase or creatine kinase (CPK) is an important protein enzyme found in different muscles and organs in your body, including your skeletal muscles, brain, and heart. Health Information: Creatine Kinase: Why It Is Done; [updated 2018 Jun 25; cited 2019 Jun 12]; [about 3 screens]. Chronic migraine is the most severe stage of frequent migraines, with more than 15 headache days a month. Trauma and other conditions that damage the skeletal muscle are also associated with an elevated creatine kinase level. If wikiHow has helped you, please consider a small contribution to support us in helping more readers like you. After being filtered, these waste products are then expelled from your body in urine. Remember, always speak to your doctor before taking any supplements, because they may interfere with your health condition or your treatment/medications! There are 21 references cited in this article, which can be found at the bottom of the page. You may have slight pain or bruising at the spot where the needle was put in, but most symptoms go away quickly. The .gov means its official. Include your email address to get a message when this question is answered. "This was exactly what I was looking for. Youre taking statins (medications used to lower cholesterol) and, Have certain chronic conditions like muscular dystrophy, Infection due to improper sanitary practices, Soreness and bruising after the blood draw. Studies suggest that after strenuous exercise, an increase in creatine kinase (muscle damage) can be attenuated by consuming enough carbs, protein, and antioxidants [82]. 2001;26 Suppl:S79-102. Health Encyclopedia: Creatine Kinase (Blood); [cited 2019 Jun 12]; [about 2 screens]. In a study of 1,444 subjects, higher CK levels were linked with higher BMI and waist-to-hip ratio [18]. Creatinine is a chemical waste product of creatine, an amino acid made by the liver and stored in the liver. Uses, Side Effects, and Procedure of a Bilirubin Test, Transaminitis (Liver Enzyme) Result: Meaning and Causes, Cardiac Biomarkers, Cardiac Enzymes, and Heart Disease, Myophosphorylase Deficiency: Overview and More. Heart disease and kidney disease. A neurologist is an expert in diagnosing and Madison (WI): University of Wisconsin Hospitals and Clinics Authority; c2019. They can include: The symptoms of high creatinine can depend on the condition thats causing it. Last medically reviewed on July 24, 2019. {"smallUrl":"https:\/\/www.wikihow.com\/images\/thumb\/2\/29\/Lower-CPK-Levels-Naturally-Step-9.jpg\/v4-460px-Lower-CPK-Levels-Naturally-Step-9.jpg","bigUrl":"\/images\/thumb\/2\/29\/Lower-CPK-Levels-Naturally-Step-9.jpg\/aid4510115-v4-728px-Lower-CPK-Levels-Naturally-Step-9.jpg","smallWidth":460,"smallHeight":345,"bigWidth":728,"bigHeight":546,"licensing":"

License: Creative Commons<\/a>
\n<\/p>


\n<\/p><\/div>"}, Educational website from one of the world's leading hospitals, {"smallUrl":"https:\/\/www.wikihow.com\/images\/thumb\/b\/b7\/Lower-CPK-Levels-Naturally-Step-1.jpg\/v4-460px-Lower-CPK-Levels-Naturally-Step-1.jpg","bigUrl":"\/images\/thumb\/b\/b7\/Lower-CPK-Levels-Naturally-Step-1.jpg\/aid4510115-v4-728px-Lower-CPK-Levels-Naturally-Step-1.jpg","smallWidth":460,"smallHeight":345,"bigWidth":728,"bigHeight":546,"licensing":"

License: Creative Commons<\/a>
\n<\/p>


\n<\/p><\/div>"}, Collection of medical information sourced from the US National Library of Medicine, Harvard Medical School's Educational Site for the Public, {"smallUrl":"https:\/\/www.wikihow.com\/images\/thumb\/c\/c9\/Lower-CPK-Levels-Naturally-Step-10-Version-2.jpg\/v4-460px-Lower-CPK-Levels-Naturally-Step-10-Version-2.jpg","bigUrl":"\/images\/thumb\/c\/c9\/Lower-CPK-Levels-Naturally-Step-10-Version-2.jpg\/aid4510115-v4-728px-Lower-CPK-Levels-Naturally-Step-10-Version-2.jpg","smallWidth":460,"smallHeight":345,"bigWidth":728,"bigHeight":546,"licensing":"

License: Creative Commons<\/a>
\n<\/p>


\n<\/p><\/div>"}, Journals of the American Heart Association. CK increased in all subjects after downhill walking (P < .01), but neither the relative peak change (expressed as group mean difference with 95% confidence intervals: 43.52% [-196.41, 283.45]) nor the absolute peak change (67.38 U/L [-121.55, 256.31]) relative to baseline was different between groups (P = .46 and .71, respectively). An elevated creatine kinase can signal a heart attack or other emergency. Green tea is also effective at lowering your cholesterol. Los Angeles: Cedars-Sinai; c2019. stiffness. Avoid eating lots of protein-rich foods, like meat, eggs, and milk, since these increase your muscle mass, which can lead to increased CPK levels. Your doctor will interpret this test, taking into account your medical history and other test results, and will repeat it if necessary. The site is secure. Severe muscle damage due to injury or chronic disease. The creatine kinase test is a blood test that checks whether the CK levels in your blood are elevated. The most important thing is to work with your doctor to find out whats causing your low creatine kinase and to treat any underlying condition! Int J Sport Nutr Exerc Metab. ", much bigger health issues at a later stage. The most common cause of low creatine kinase levels is muscle wasting (muscle atrophy) due to physical inactivity, illnesses, or old age [85]. In another study of over 10,000 adults, overweight and obese men had almost 2 times greater odds of having elevated CK [19]. If you think you may have a medical emergency, immediately call your doctor or dial 911. Read our. Symptoms of the condition include: Diabetes is a condition in which your blood sugar is too high. Available from: National Heart, Lung, and Blood Institute [Internet]. If you have any questions or comments, please dont hesitate to contact us. Aerobic exercise, strength training, and stretching and flexibility all contribute to a healthy body. Symptoms of muscular disorders can include: Most healthcare providers now test for elevated cardiac troponin levels, another protein, instead of the CK-MB test when testing for signs of a heart attack. Risks of getting your blood drawn for a CK test are minimal but may include: A CK test doesnt provide a diagnosis. If you have higher than normal CK-MM enzymes, it may mean you have a muscle injury or disease, such as muscular dystrophy or rhabdomyolis. This test measures the amount of creatine kinase (CK) in the blood. Treatment will depend on the underlying condition causing the elevated levels. Some general symptoms include: Symptoms of congestive heart failure can include: Your urinary tract can become blocked due to a variety of things, such as kidney stones, an enlarged prostate, or tumors. Madison (WI): University of Wisconsin Hospitals and Clinics Authority; c2019. 2021 May 27;13(6):1825. doi: 10.3390/nu13061825. Our team has a wealth of experience in the fields of journalism, TV and video production and the healthcare industry. Creatine kinase (CK) levels. Use it to try out great new products and services nationwide without paying full pricewine, food delivery, clothing and more. By using our site, you agree to our. The more inflammation there is, the lower creatine kinase levels can get. Serum CK ranges might improve to as a lot as 30 occasions the higher restrict of regular inside 24 hours of strenuous bodily exercise, then slowly decline over the subsequent 7 days. Generally speaking, high levels of creatinine can indicate that your kidneys arent working well. heaviness. This image may not be used by other entities without the express written consent of wikiHow, Inc.
\n<\/p>


\n<\/p><\/div>"}, {"smallUrl":"https:\/\/www.wikihow.com\/images\/thumb\/1\/10\/Lower-CPK-Levels-Naturally-Step-15-Version-3.jpg\/v4-460px-Lower-CPK-Levels-Naturally-Step-15-Version-3.jpg","bigUrl":"\/images\/thumb\/1\/10\/Lower-CPK-Levels-Naturally-Step-15-Version-3.jpg\/aid4510115-v4-728px-Lower-CPK-Levels-Naturally-Step-15-Version-3.jpg","smallWidth":460,"smallHeight":345,"bigWidth":728,"bigHeight":546,"licensing":"

\u00a9 2023 wikiHow, Inc. All rights reserved. wikiHow, Inc. is the copyright holder of this image under U.S. and international copyright laws. Some symptoms of kidney failure to watch for include: You should always call your doctor if youre experiencing new, unexplained, or recurring symptoms, particularly if theyre consistent with conditions such as kidney disease, diabetes, or heart disease. Drug-induced renal disorders. What Is a Comprehensive Metabolic Panel (CMP)? 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. The creatine kinase response to eccentric exercise with atorvastatin 10 mg or 80 mg. Increases in creatine kinase with atorvastatin treatment are not associated with decreases in muscular performance. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). In a large community study of over 12,000 people in Norway, people who had elevated CK levels were re-tested after 3 days of rest. To lower your CPK levels naturally, eat foods that can help lower your cholesterol, like Chinese red yeast rice, walnuts, almonds, and artichokes. CK ranges range considerably by intercourse and race.5 Potential causes embody variations in muscle mass or whole physique mass and inherited variations within the permeability of the sarcolemma to CK.6 There may be additionally a small discount in CK ranges as individuals age.2. None of these strategies should ever be done in place of what your doctor recommends or prescribes! Cardiac symptoms that may occur along with elevated creatine kinase. The precise distribution of serum CK ranges in a wholesome inhabitants is markedly skewed towards increased values and is nongaussian.13 A 97.5% regular threshold is related to a a lot decrease false-positive price and is really useful by the European Federation of Neurological Societies (now the European Academy of Neurology).4 This group additionally recommends pursuing additional investigation just for sufferers whose stage is no less than 1.5 occasions the higher restrict of regular; this threshold ends in solely a small discount in sensitivity. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. Elevated creatine kinase may accompany other symptoms of a heart attack including: This article made me feel better and I also found out there are other uses for ginkgo biloba besides memory. This information boosted my. Its often detected during a routine health screening. We use cookies to make wikiHow great. Symptoms of atherosclerosis dont usually occur until an artery is severely narrowed or completely blocked. What diseases would produce high ck levels? wikiHow, Inc. is the copyright holder of this image under U.S. and international copyright laws. (n.d.). While it plays an important role in your metabolism, high CPK levels may mean you have damaged your brain, heart, or muscle tissue. Exercise is known to contribute to increased levels of potassium, urea, creatinine, creatine kinase, lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alkaline phosphatase, bilirubin, uric acid, as well as the white blood cell count. By signing up you are agreeing to receive emails according to our privacy policy. Serum creatine kinase (CK) levels are higher after eccentric, muscle-damaging exercise in statin-treated patients. The rate may be higher in 'real-world', less controlled settings. Fish are a great source of protein you can eat on the Mediterranean diet. We believe that the most accurate information is found directly in the scientific source. A study of over 700 athletes suggests that normal reference ranges for athletes may be over two times higher than normal ranges: 82 1,083 U/L in men and 47 513 U/L in women [12]. When muscles break down, they release CK, elevating the protein levels in your blood. The enzyme level continues to rise for the first 18 to 24 hours after a heart attack and slowly returns to normal after a few days. Available from: UW Health [Internet]. Health Effects of High Creatine Kinase Level, Health Effects of Low Creatine Kinase Levels, Joe Cohen flipped the script on conventional and alternative medicine and it worked. Healthline Media does not provide medical advice, diagnosis, or treatment. Unauthorized use of these marks is strictly prohibited. is a clickable link to peer-reviewed scientific studies. There is very little risk to having a blood test. Most laboratories use the central 95% of observations in white individuals as a reference vary for serum CK, assuming that ranges have a gaussian (bell-shaped) distribution, which is normally about 0 to 200 IU/L. Elevated blood sugar levels can lead to a variety of health problems, one of which is kidney disease. If you are concerned about your CPK levels and think that they might be indicating a heart condition, talk to your doctor right away. Comment * document.getElementById("comment").setAttribute( "id", "a9a570d4abadcab73d4b6a6a9ba17a72" );document.getElementById("a6cbe26769").setAttribute( "id", "comment" ); Save my name, email, and website in this browser for the next time I comment. Founded in 1998, the Arthritis Center at Johns Hopkins is dedicated to providing quality education to patients and healthcare providers alike. WebThe most serious adverse reaction is significant elevation of creatine kinase (CK) leading to rhabdomyolysis. Creatine kinase (CK) Lets take a closer look at high creatinine, the symptoms that go along with it, and when to see a doctor. (2016). If your results show you have a higher than normal level of CK, it may mean you have an injury or disease of the muscles, heart, or brain. Some potential causes include infections or autoimmune diseases like lupus and Goodpasture syndrome. Elevated creatine kinase levels are present when there is destruction of cardiac or skeletal muscle. Creatine kinase levels can also be increased in brain injury, such as stroke. The elevation is detected through a simple blood test. Causes of elevated creatine kinase doing what needs to be done to keep my heart healthy. Creatinine is a waste product thats made by your muscles. Learn more signs of kidney failure. Vertigo Home Remedies: 11 Solutions Backed By Research. Veggi K FT, Machado M, Koch AJ, Santana SC, Oliveira SS, Stec MJ. A health care professional will take a blood sample from a vein in your arm, using a small needle. High creatinine levels are often caused by kidney damage, which prevents normal elimination of creatinine through the urine. According to Mayo Clinic, the normal range of creatinine (for an adult) in the blood is typically: Creatinine levels above the normal range values may be considered high. Disclaimer. Eating a lot of cooked meat may show a false positive, or high amount of CPK levels in your blood. It doesnt provide a full picture of your health, so healthcare providers typically perform other tests to make a diagnosis. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. This test can help show if you have damage to your heart or other muscles. Should high levels of creatine kinase concern you? Many of these conditions can cause damage or disease that impacts kidney function. Some medications can cause damage to the kidneys and impair their ability to function. Foods high in soluble fiber, like oats, apples, carrots, and broccoli, can also help stop your intestines from absorbing too much cholesterol. Rhabdomyolysis is a syndrome characterized by muscle necrosis and the release of intracellular muscle constituents into the circulation. A BUN of 29 is yes elevated, but nothing crazy. But another test, called troponin, has been found to be better at detecting heart damage. Our website services, content, and products are for informational purposes only. What is the treatment for high levels of creatine kinase? 4 Neurologist Tips for People With Tardive Dyskinesia. High creatinine levels can indicate a range of underlying health conditions, including kidney infection and kidney failure. References The low normal limit for both men and women is approximately 20 30 U/L (0.34 0.51 ukat/L). A similar lack of treatment effect was observed for muscle soreness (11.03 mm [-9.49, 31.55]), pain severity (0.77 pts [-0.95, 2.50]), and pain interference (1.02 pts [-1.25, 3.29]) with P-values for group comparisons = 0.27, 0.36, and 0.35, respectively. Other names: CK, total CK, creatine phosphokinase, CPK. Bookshelf Approximately half of the creatine in your body is naturally produced by your kidney, liver and pancreas, the University of Maryland Medical Center notes 4.Foods high in creatine include lean red meat and fish such as herring, salmon However, it could also be caused by a neuromuscular, metabolic, or rheumatologic condition, like arthritis or lupus. Elevated levels of CK-MB can mean you have some sort of heart damage. Shahrbaf FG, et al. Learn more about laboratory tests, reference ranges, and understanding results. Similarly, in 4,500 people, CK levels were higher in people with greater body mass [4]. The Vand Sufferers who nonetheless have elevated CK after considering the 97.5% threshold, repeat testing after every week of relaxation, and a stage greater than 1.5 occasions the higher restrict of regular for intercourse and race ought to first be evaluated for the various nonneuromuscular circumstances that may trigger elevated CK (Desk 1).79. FOIA Available from: National Institute of Neurological Disorders and Stroke [Internet]. Depending on the type and level of CK found, it can mean you have damage or disease of the skeletal muscles, heart, or brain. Clipboard, Search History, and several other advanced features are temporarily unavailable. Your doctor may want to confirm these values by using a urine test or by repeating the blood test. The Application of Creatine Supplementation in Medical Rehabilitation. You can learn more about how we ensure our content is accurate and current by reading our. We tested the hypothesis in this pilot study that creatine (Cr) monohydrate supplementation would reduce the CK response to eccentric exercise in patients using statins to determine if Cr supplementation could be a strategy to mitigate statin-associated muscle symptoms in physically active individuals. They discovered that obese and overweight people have more fast-twitch (type II) muscle fibers and less slow-twitch (type I) muscle fibers. Conditions affecting the heart and blood vessels, such as atherosclerosis and congestive heart failure, can also impact kidney function. 1. In many cases, medications can help resolve high creatinine levels by treating the condition thats causing the increase. Your doctor will work with you to evaluate and interpret your results and what they may mean. If you have higher than normal CK-MB enzymes, it may mean you have an inflammation of the heart muscle or are having or recently had a heart attack. Dominique Fontaine, BSN, RN, HNB-BC, HWNC-BC, drug toxicity (drug-induced nephrotoxicity), fluid retention, particularly in your lower body, pain localized to your back, side, or groin, urine that appears dark, cloudy, or bloody, blood in the urine, which may make it appear pink or brown, urine that appears foamy due to high levels of protein, fluid retention in the face, hands, and feet, sensations of numbness or tingling in the hands and feet, stroke-like symptoms, such as paralysis or trouble speaking, difficulty breathing or shortness of breath, passing small amounts of urine or having a weak urine stream. Cocaine increases CK levels [59, 60, 61]. (2016). (2017). A small study with 14 men showed that sports massage 2 hours after exercise decrease CK levels [83].