In addition, you should use effective birth control while youre taking Prolia. See what this means for you in the chart below. to treat osteoporosis in males* and in females* whove gone through, to treat osteoporosis caused by long-term use of, metabolic bone disease, such as Hajdu-Cheney syndrome and juvenile. Prolia contains the active drug denosumab, and Reclast contains the active drug zoledronic acid. There arent any studies that have compared these two drugs to each other. Do not treat yourself. So, dont be afraid to ask questions or offer feedback on your treatment. Common side effects of Prolia can vary depending on which condition the drug is being used to treat. Pregnancy. Its not known if Prolia is safe or effective for use in children. These types of medications come in forms that are taken by mouth and forms that are given by injection. Learn more about your health after menopause. Are there lifestyle changes that can help my osteoporosis. Pay special attention to your dental hygiene. You may need to stop using the medicine for a short time. They will also explain how much youll be given and how often. Like most drugs, Prolia may cause mild or serious side effects. The drug may also be used off-label for osteopenia, but usually, you dont need medications for osteopenia. It does the same thing that. (Chlorhexidine helps kill germs in your mouth.). Youll receive Prolia from a healthcare professional as an injection under the skin in one of the following areas: Prolia contains the active drug denosumab, which is a biologic medication. Sciatica is described as a shooting pain that travels from the lower back down a leg. Do any of yall know? WebProlia is used to treat osteoporosis in women after menopause and in men, and in people With osteopenia, your bone mineral density (BMD) is lower than usual. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Last updated on Feb 8, 2023. Specifically, Prolia works by blocking a protein called RANK. Theyll discuss with you other treatments to help prevent bone loss. More common side effects in females* who received Prolia for osteoporosis after menopause included: More common side effects in males* who received Prolia for osteoporosis included: More common side effects in people who received Prolia for osteoporosis due to drugs called glucocorticoids included: More common side effects in people who received Prolia to stop bone thinning due to certain cancer treatments included: For a complete list of all the side effects reported with Prolia, see the drugs prescribing information. It comes as a liquid solution thats given as an injection. Some reports may have incomplete information. It can have some side effects, but these may depend on who uses it. Having dental procedures, including tooth extractions, during Prolia treatment may increase your risk of dental side effects. You should not breastfeed while using this medicine. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Prolia is a prescriptionmedicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body. They may want to check for other causes. Different individuals may respond to medication in different ways. Prolia (denosumab) and Reclast (zoledronic acid) are injections that can be used to treat or prevent osteoporosis in postmenopausal women. In certain cases, Prolia may have contraindications (not be recommended) for you due to a higher risk for side effects. (A low blood calcium level is a possible side effect of Prolia.). Prolia isnt known to cause any harmful interactions with alcohol. But some females* who received Prolia for osteoporosis after menopause had to stop Prolia treatment due to back pain. Prolia can also cause low calcium levels. If they find any cavities or infection, theyll typically delay having you receive Prolia until your dental problems are treated. Hair loss wasnt reported as a side effect during clinical trials of Prolia. You may want to know how Prolia compares to the medication Tymlos. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. Some people who take Prolia develop severe bone, joint, or muscle pain. Visit your doctor or health care professional for regular checks on your progress. They can give you more details about this possible side effect and suggest ways to manage it. Fracture in the spine after stopping Prolia treatment. You may need to have a negative pregnancy test before starting this treatment. Your doctor will recommend the dosage of Prolia thats right for you. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are receiving this medicine. Monoclonal antibodies are made to target and destroy only certain cells in the body. Drug class: Miscellaneous bone resorption inhibitors. Do not become pregnant while taking this medicine or for 5 months after stopping it. Its possible that some of Prolias side effects may be long term, but theyre rare. It may not cover all possible information. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Prolia comes as a solution thats given as an injection under your skin. Protect from light and do not freeze. Is the ketogenic diet right for autoimmune conditions? Prolia has active ingredients of denosumab. These lists dont include all possible side effects. If youre concerned about tingling while using Prolia, talk with your doctor. You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or; if you are pregnant. Serious side effects from Prolia can occur, but they arent common. Youll likely receive Prolia long term if you and your doctor decide that the drug is effective and safe for you. You should also talk with them if you have any serious side effects during Prolia treatment. Theyll likely suggest other treatment options for your condition. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). Xgeva is used to treat a high calcium level due to cancer and to prevent bone fractures and other bone problems caused by multiple myeloma or cancer bone metastases. Prescribing Information and If you develop high cholesterol with Prolia, your doctor can guide you on which treatment options are right for your condition. You should receive your missed injection as soon as possible. Theyre commonly used to treat osteoporosis. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.) For Xgeva, talk to your pediatrician regarding the use of this medicine in children. Talk with your doctor about which other treatments are better choices for you. It may also be higher if you have dental work done while youre taking Prolia. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. They may recommend ways to ease your symptoms and determine whether you should keep taking Prolia. You do not give Prolia to yourself. Prolia and Evenity are both biologic medications, but Prolia contains the active drug denosumab, while Evenity contains the active drug romosozumab-aqqg. We avoid using tertiary references. But its believed that these side effects are rare. Below, we answer some common questions about taking Prolia. Learn more about the unique risk factors for osteoporosis in, Osteoporosis weakens bones, which leads to breaks in the hips, wrists, and spine. But its not clear whether this side effect occurred in clinical studies. (A placebo is a treatment with no active drug.). To learn how Prolia and Tymlos are alike and different, see this comparison. But certain choices and habits accelerate the process. This can cause your weight to change and may explain any weight gain since starting Prolia treatment. It is important not to miss your dose. This makes your bones weak and increases your risk for bone fractures or breaks. Musculoskeletal pain refers to pain in your bones, muscles, tendons, and ligaments. To learn more about these two drugs, check out this drug article. Continue reading, Prolia is a prescription medicine injected under the skin (called a subcutaneous injection) and is given once every 6 months. Sciatica was a less common side effect in females* who received Prolia for osteoporosis after menopause. Hair loss with Prolia is rare, and whether Prolia is responsible for this effect isnt known. They include: not getting enough calcium and vitamin D smoking drinking too much alcohol using certain medications, such as corticosteroids and anticonvulsants not getting enough weight-bearing exercise (at least 30 minutes on most days). But theyre each effective in treating osteoporosis and preventing bone loss. if you are taking medicine that lower your blood calcium levels. The fractures may require surgeries, take several months to heal, or both. Mild side effects that have been reported with Prolia include: These side effects may be temporary, lasting a few days or weeks. 2023 Healthline Media UK Ltd, Brighton, UK. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. (Biosimilars are like generic drugs. They can also suggest ways to relieve this side effect. Do not reuse a needle or syringe. Women going through menopause have a higher risk of developing osteoporosis. But doing so can cause more bone breakdown and increase your risk for bone fractures. The lists below describe some of the more common side effects that Prolia may cause. If you drink alcohol, talk with your doctor about how much is safe to drink with your condition. Our website services, content, and products are for informational purposes only. Prolia is available as the biosimilar medication denosumab. Will my fracture risk come back if I stop Prolia treatment? But before taking Prolia, be sure to tell your doctor about all medications you take (including prescription and over-the-counter types). The risk is real, but rare. Get emergency medical help if you have signs of an allergic reaction to Prolia: hives, itching, rash; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. If youve been diagnosed with osteoporosis, your doctor may discuss Prolia with you. Also describe any vitamins, herbs, or supplements you use. As with most drugs, Prolia can cause an allergic reaction in some people. The use of the eHealthMe site and its content is at your own risk. Special care may be needed. Prolia is an injection prescribed for certain adults with osteoporosis, which Xgeva is also used to treat giant cell tumor of the bone. If your pain becomes severe, your doctor may recommend other treatment options to replace Prolia. The phase IV clinical study analyzes what interactions people who take Prolia and Calcium have. Serious skin infections may occur, but are uncommon If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using Prolia. For more information about how these medications compare with each other, ask your doctor. Prolia injections administered by a healthcare professional. RA is an autoimmune condition in which your immune system attacks your joints. You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia. This is because your body doesnt make enough bone, or it loses bone faster than it makes new bone. You may need to go to the hospital for treatment. Do not share this medicine with another person, even if they have the same symptoms you have. Had parathyroid or thyroid surgery (glands located in your neck), Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome), Have kidney problems or are on kidney dialysis, Are taking medicine that can lower your blood calcium levels, Plan to have dental surgery or teeth removed, Are breast-feeding or plan to breast-feed. Policy. Your doctor can give you more information about the risks and benefits and how Reclast compares with Prolia. Scientists use genetic rewiring to increase lifespan of cells, Beyond amyloid and tau: New targets in developing dementia treatments, Napping longer than 30 minutes linked to higher risk of obesity and high blood pressure, Activity 'snacks' could lower blood sugar, complication risk in type 1 diabetes, In Conversation: Investigating the power of music for dementia, 11 ways to increase bone density naturally, 14 of the best calcium supplements in 2023. Yes, if recommended by your doctor, you can stop taking Prolia. You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. Continue reading, Prolia (denosumab) does increase bone density. But hair loss has been reported by people who have taken Prolia since then. Check with your doctor if you have more questions about these drugs. Vertigo (dizziness) was reported in some people who received Prolia for osteoporosis, but this was a less common side effect. Call your doctor for instructions if you miss a dose or miss an appointment for your Prolia injection. They also include any added costs of the drug being given by a healthcare professional. Use effective birth control while using this medicine and for at least 5 months after your last dose. Prolia is usually given once every 6 months. Instead, your doctor may recommend that you make certain changes to your diet, such as increasing your calcium and vitamin D intake. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. You can often relieve mild pain in your back or bones with an over-the-counter (OTC) pain medication. By stopping RANKL from binding to its receptor Prolia reduces bone breakdown, bone loss, bone pain, and other bone complications. In fact, bone breakdown is higher in the first several months after you stop Prolia. Find out what it means, how its calculated, and more. If you have low calcium levels, you should not take Prolia. The most common side effects of Prolia in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat). Its recommended that calcium and vitamin D supplements be taken Prolia may cause several side effects. This may include acetaminophen (Tylenol), naproxen (Aleve), or ibuprofen (Advil, Motrin). Prolia contains the active drug denosumab, while Fosamax contains the active drug alendronate. have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia. If youre concerned about unexplained weight gain while using Prolia, talk with your doctor. Take only the amount of calcium and vitamin D that your doctor has prescribed. Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. NOTE: This medicine is only for you. Learn how to slow it down and fortify your body against it. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Prolia is used in adults to treat osteoporosis or bone loss in people who: who cannot use another osteoporosis medicine or these medicines did not work well. What Health Changes Should You Expect Postmenopause? Take calcium and vitamin D as your doctor tells you to help prevent low blood calcium. Lifestyle changes that can help improve cholesterol levels include exercising regularly and eating a healthy diet. Symptoms may include jaw pain or numbness, red or swollen gums, loose teeth, gum infection, or slow healing after dental work. What are some frequently asked questions about Prolia? You might like to know how Prolia and the drug Evenity compare. According to the American Dental Association, your risk of this problem may increase if you receive denosumab (the active drug in Prolia) for longer than 2 years. If you have any questions about Prolias side effects, talk with your doctor. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. * Approximation only. Vitamin D The body needs vitamin D to absorb calcium. Use of the term male in this article refers to sex assigned at birth. After you have taken Prolia out of the refrigerator, you may keep it at room temperature for up to 14 days. Some people using Prolia have developed bone loss in the jaw, also called osteonecrosis of the jaw. Some people may have dental or jaw-related issues with Prolia use. Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. If you have low blood calcium, it may get worse during treatment. This medicine may cause jaw bone problems (osteonecrosis). The Prolia is making my leg bones and jaw bones hurt. Prolia is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments You should always consult your doctor or another healthcare professional before taking any medication. Usually, but it depends. Your doctor may also have you take certain supplements that contain calcium and vitamin D while youre receiving Prolia. Its used to lower the risk of bone fractures in people with certain other conditions. NOTE: This sheet is a summary. If your doctor says this is safe for you, youll be shown how to inject the medication. This increases your risk for bone fractures. People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk.